Detailed view for Tb927.11.16090

Basic information

TDR Targets ID: 11804
Trypanosoma brucei, outer dynein arm docking complex, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.2467 | Length (AA): 634 | MW (Da): 72146 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0015629   actin cytoskeleton  
GO:0005198   structural molecule activity  
GO:0007155   cell adhesion  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
25 222 3fb2 (A) 1335 1536 15.00 0 0.19 0.359803 -0.36
26 246 4tql (A) 14 228 15.00 0 0.25 0.52008 -1.11
30 381 1u4q (A) 1664 1978 13.00 0 0.99 0.567705 0.29
61 181 5caj (A) 84 205 29.00 0.013 0.23 0.392452 0.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_130053)

Species Accession Gene Product
Drosophila melanogaster Dmel_CG14905   CG14905 gene product from transcript CG14905-RA
Echinococcus granulosus EgrG_000441000   axonemal p66.0
Echinococcus multilocularis EmuJ_000441000   axonemal p66.0
Giardia lamblia GL50803_114462   Axonemal p66.0
Homo sapiens ENSG00000173093   coiled-coil domain containing 63
Homo sapiens ENSG00000105479   coiled-coil domain containing 114
Leishmania braziliensis LbrM.32.3150   outer dynein arm docking complex, putative;with=GeneDB:Linj32_V3.3050
Leishmania donovani LdBPK_323050.1   outer dynein arm docking complex, putative
Leishmania infantum LinJ.32.3050   outer dynein arm docking complex protein;with=GeneDB:Linj32_V3.3050
Leishmania major LmjF.32.2900   outer dynein arm docking complex, putative;with=GeneDB:Linj32_V3.3050
Leishmania mexicana LmxM.31.2900   hypothetical protein, conserved
Mus musculus ENSMUSG00000040189   coiled-coil domain containing 114
Mus musculus ENSMUSG00000043036   coiled-coil domain containing 63
Neospora caninum NCLIV_037230   hypothetical protein, conserved
Schistosoma japonicum Sjp_0013800   Coiled-coil domain-containing protein 114, putative
Schistosoma mansoni Smp_000580   hypothetical protein
Schmidtea mediterranea mk4.002554.00  
Schmidtea mediterranea mk4.011127.00  
Schmidtea mediterranea mk4.004618.00  
Schmidtea mediterranea mk4.024286.00  
Trypanosoma brucei gambiense Tbg972.11.18030   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.16090   outer dynein arm docking complex, putative
Trypanosoma congolense TcIL3000.11.16010   outer dynein arm docking complex, putative
Trypanosoma cruzi TcCLB.509073.40   outer dynein arm docking complex protein
Trypanosoma cruzi TcCLB.508707.170   outer dynein arm docking complex, putative
Toxoplasma gondii TGME49_269160   outer dynein arm docking complex protein ODA1, putative
Trichomonas vaginalis TVAG_238220   conserved hypothetical protein
Trichomonas vaginalis TVAG_120000   protein NUF1, putative
Trichomonas vaginalis TVAG_026430   conserved hypothetical protein
Trichomonas vaginalis TVAG_567400   conserved hypothetical protein
Trichomonas vaginalis TVAG_456520   conserved hypothetical protein

Essentiality

Tb927.11.16090 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.7750 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.7750 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.7750 this record Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.7750 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_269160 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.11.16090 (Trypanosoma brucei), outer dynein arm docking complex, putative
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